|
KMID : 1377020210180010113
|
|
Tissue Engineering and Regenerative Medicine
2021 Volume.18 No. 1 p.113 ~ p.125
|
|
|
Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment
|
|
Mou Donggang
Yu Qunying
Zhang Jimei
Zhou Jianping
Li Xinmin
Zhuang Weiyi
Yang Xuming
|
|
|
Abstract
|
|
|
Background: Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the difficulty of long-term maintenance of efficacy.
Methods: In this study, an injectable and self-healing hydrogel was synthesized by in situ crosslinking of N-carboxyethyl chitosan (N-chitosan), adipic acid dihydrazide (ADH), and hyaluronic acid?aldehyde (HA-ALD).
Results: This supramolecular hydrogel sustains good biocompatibility for chondrocytes. Intra-articular injection of this novel hydrogel can significantly alleviate the local inflammation microenvironment in knee joints, through inhibiting the inflammatory cytokines (such as TNF-α, IL-1β, IL-6 and IL-17) in the synovial fluid and cartilage at 2- and even 12-weeks post-injection. Histological and behavioral test indicated that hydrogel injection protected cartilage destruction and relieved pain in OA rats, in comparison to HA injection.
Conclusion: This kind of novel hydrogel, which is superior to the traditional HA injection, reveals a great potential for the treatment of OA.
|
|
|
KEYWORD
|
|
|
Chitosan, Hyaluronic acid, Hydrogel, Osteoarthritis, Intra-articular injection
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|
|